Biomimetic mineralized mesenchymal stem cell-derived exosomes for dual modulation of ferroptosis and lactic acid-driven inflammation in acute liver injury therapy.

• Tác giả: Zongwei Hu, Zengguang Jia, Ruixin Kang, Lin Luo, Xiuhua Pan, Qi Shen, Ziqi Shen, Yiwei Tian, Jun Zhang, Xiawei Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 617.106 Nonsurgical therapy
• Thông tin xuất bản: United States : Journal of colloid and interface science , 2025
• Bộ sưu tập: NCBI
• ID: 702532

Tóm tắt

Acute liver injury (ALI) is characterized by rapid and severe hepatocellular damage, leading to ferroptosis and an exacerbated inflammatory response. Mesenchymal stem cell-derived exosomes (MSC-exo) have emerged as a promising therapeutic strategy for ALI due to their ability to deliver antioxidants and stabilize solute carrier family 7 members 11 (SLC7A11)/glutathione peroxidase 4 (GPX4) system. In this study, we developed a novel engineered exosome, MSC-exo/MnO