Short-chain chlorinated paraffins (SCCPs) are a complex mixture of chlorinated derivatives of n-alkanes with a chain length of 10-13 carbon atoms. SCCPs have been extensively used in industrial applications, although an alarming concern is increasingly raised in hazarding environmental matrices and biological organisms due to the environmental persistence, bioaccumulation potential, biotoxicity, and long-range atmospheric transport. Herein, this study conducted a critical review of human internal exposure to SCCPs and its concerning health risks by thoroughly analyzing 63 relevant articles screened in online databases, including the Web of Science, PubMed, Elsevier ScienceDirect, and China National Knowledge Infrastructure (CNKI). The review focused on various biological matrices, including blood, breast milk, and placenta, to assess human internal exposure to SCCPs, and summarized systematic health risk assessments for external exposures across different population groups. The primary exposure routes of SCCPs were dietary intake and dust ingestion and dermal absorption. Particularly, vulnerable population groups of infants, children, and occupational workers suffered from an elevated health risk of SCCPs, with the daily SCCPs intake approaching or exceeding the tolerable daily intake (TDI). So far, existing literature on an internal exposure to SCCPs by detecting human biological samples is insufficient and lacks a comprehensive, life cycle-wide monitoring of vulnerable and occupational populations. The relationship between human exposure to SCCPs and the consequent adverse health effects requires a further deep mining. Moreover, there is a lack of established exposure warning guidance values, and available internal exposure assessment models of SCCPs are currently limited. The future research priority is to knit together the assessment of human internal exposure to SCCPs and the following health risk by advanced sample pre-treatment and analytical methodologies, standardized operating procedures, and non-targeted screening combined with targeted detection techniques. Through a continuous monitoring of human internal exposure to SCCPs, clear illustration of the exposure-effect relationship and comprehensive health risk assessments via multiple exposure routes, these results shed lights on developing and revising regulatory frameworks for governing the production and handling of SCCPs.