Personalizing Biologic Therapy in Psoriasis: Development, Validation, and User Testing of a Precision-Dosing Dashboard.

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Tác giả: Monica Arenas-Hernandez, Zehra Arkir, Jonathan Barker, David Baudry, Sarah Chapman, Bola Coker, Tejus Dasandi, Jenny Leung, Satveer K Mahil, Chioma Nwaogu, Andrew Pink, Kingsley Powell, Krystal Rawstron, Catherine H Smith, Joseph F Standing, Charlotte M Thomas, Richard Woolf

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : The Journal of investigative dermatology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 702621

An increasing number of individuals receiving psoriasis biologics achieve clear/nearly clear skin (disease control). Clinical trial data indicate that some maintain disease control with lower doses, especially those with higher serum drug concentrations. This indicates the potential of model-informed precision dosing, an advanced therapeutic drug-monitoring technique, to guide dose minimization. We developed, validated, and tested a precision-dosing dashboard. We applied a model-informed precision-dosing approach that leveraged Bayesian estimation to predict individual pharmacokinetic parameters for personalized dosing recommendations. A pharmacokinetic model of the exemplar biologic risankizumab derived from phases I-III psoriasis trial data (13,123 observations from 1899 patients) was externally validated using real-world data from the United Kingdom. The Bayesian model (posterior prediction: mean absolute error = 0.89 mg/l, mean percentage error = 19.55%, root mean square error = 1.24 mg/l, R
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