Intratumour oxidative hotspots provide a niche for cancer cell dissemination.

• Tác giả: Mike Aoun, Tomohiro Doura, Itaru Hamachi, Hiroshi Harada, Rikard Holmdahl, Keisuke Inoue, Masahiro Inoue, Taketoshi Kajimoto, Shigeki Kiyonaka, Ryuhei Kurogi, Yasuo Mori, Takahiro Nakayama, Haruki Omatsu, Kunishige Onuma, Reiko Sakaguchi, Laura M Selfors, Jiacheng H Sun, Harufumi Suzuki, Yuki Tado, Nobuaki Takahashi, Makoto Uchiyama, Yoshifumi Ueda, Yuji Yamada, Tetsuya Yano
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature cell biology , 2025
• Bộ sưu tập: NCBI
• ID: 702681

Tóm tắt

Intratumour heterogeneity represents the hierarchical integration of genetic, phenotypic and microenvironmental heterogeneity. Although single-cell sequencing has clarified genetic and phenotypic variability, the heterogeneity of nongenetic, microenvironmental factors remains elusive. Here, we developed T-AP1, a tumour-targeted probe tracking extracellular H