In Silico Interim Adaptation of Proton Therapy in Head and Neck Cancer by Simultaneous Dose and Linear Energy Transfer Escalation.

• Tác giả: Mirjam K D Alsaker, Signe Danielsen, Guillermo Garrido-Hernandez, Helge Henjum, Kathrine Røe Redalen, René M Winter, Kristian Smeland Ytre-Hauge
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : International journal of radiation oncology, biology, physics , 2025
• Bộ sưu tập: NCBI
• ID: 702711

Tóm tắt

PURPOSE: The outcome of proton therapy for head and neck cancer (HNC) varies considerably. We investigated the feasibility of adapting proton therapy plans based on METHODS AND MATERIALS: A semiautomated method was used to segment the BTV from RESULTS: Dose-LET adapted proton therapy plans achieved 10% dose escalation and mean dose-averaged LET (LET CONCLUSIONS: Our in silico study showed that dose-LET escalation in proton therapy integrating a variable-RBE model may improve proton therapy for patients with HNC. Clinical evaluation of such a biological image-based dose-LET escalation in proton therapy of HNC remains to be investigated.