Immunotherapy rechallenge after significant toxicity - can it be done successfully?

• Tác giả: Brendan Adler, Timothy D Clay, Andrew Dean, Ashleigh DeMarie, Eli Gabbay, Tara McSweeney, Nisha Sikotra, Quentin Summers, Ashley Tan, Naomi van Hagen, Tom van Hagen
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Immunotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 702764

Tóm tắt

AIM: We describe a single-center burden of admissions for irAE management and rechallenge feasibility. METHODS: A retrospective single-center study of patients receiving immunotherapy between 2015-2018 assessing irAE and immunotherapy rechallenge outcomes. RESULTS: 69 of 307 patients (22%) required 124 hospitalizations for irAEs. 8 required ICU admission (2.6%). 6 (1.9%) died from irAEs. Corticosteroids were used in 96% of admissions. Additional immunosuppression was required in 26 admissions (21%). 47 of 69 patients were rechallenged (68%). The median duration between toxicity and rechallenge was 49 days (range 17-994 days). 19 of 47 rechallenged patients (40%) were admitted for subsequent irAE. 19 patients of the rechallenged group (40%) were alive at last follow-up. CONCLUSION: Immunotherapy rechallenge following prior irAE hospitalization is feasible but carries significant toxicity risk.