Emergence, prevalence and evolution of porcine reproductive and respiratory syndrome virus 1 in China from 1994 to 2024.

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Tác giả: Nanhua Chen, Shubin Li, Shubo Li, Ming Qiu, Yuejia Qiu, Kegong Tian, Jianzhong Zhu

Ngôn ngữ: eng

Ký hiệu phân loại: 912.01 Philosophy and theory

Thông tin xuất bản: United States : Virology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 702810

Porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) was first detected in Chinese swine herds during an epidemiological investigation since 1994. Even though PRRSV-1 has been existed in China for 30 years, much less attention was paid on PRRSV-1 than PRRSV-2. This review systematically evaluated the emergence, prevalence and evolution of Chinese PRRSV-1 from 1994 to 2024. Here we showed that PRRSV-1 has been detected in at least 28 regions of China, which can be divided into eight subgroups within subtype 1. During the evolution in Chinese swine herds, a large number of substitutions, insertions and deletions were identified. Recombination events were also commonly detected accompanying with nsp1-nsp3, nsp9-nsp10 and ORF2-ORF6 regions as the cross-over hotspots. Remarkably, Chinese PRRSV-1 isolates showed a trend of increasing in pathogenicity in recent years. At last, we discussed the differential detection methods and cross-protection strategies against PRRSV-1 isolates. Overall, PRRSV-1 has become one of the widely-spread viruses in China posing a significant threat to China's swine industry.
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