Cytomegalovirus (CMV) has a negative impact on overall posttransplant rehabilitation. While infection often manifests as gastrointestinal disease, pneumonitis, nephritis and others, it may be associated with psychotic symptoms. The role of CMV in etiology of schizophrenia has already been recognized but it was never described in the posttransplant psychosis. We present a case depicting development of psychosis 10 years post kidney transplantation associated with CMV disease.