Systems metabolic engineering and process optimization for efficient l-tyrosine production from high-purity glucose syrup in Escherichia coli.

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Tác giả: Zhichao Chen, Xiaoguang Fan, Changgeng Li, Lanxiao Li, Weiwei Liu, Ling Ma, Qingyang Xu, Zichen Yu, Meng Yuan

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Bioresource technology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 703150

l-tyrosine (l-tyr) is a valuable aromatic amino acid that can be produced via microbial fermentation, providing a sustainable alternative to costly and polluting chemical synthesis. However, industrial production is limited by poor strain performance and inefficient resource utilization. In this study, a high-performance Escherichia coli strain was engineered to address key fermentation bottlenecks for efficient l-tyr synthesis from high-purity glucose syrup. Initially, a "rapid channel" for l-tyr biosynthesis was established by overexpressing aroG
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