In recent years, post-mortem imaging has advanced with techniques such as Post-Mortem Computed Tomography (PMCT) and Post-Mortem Magnetic Resonance imaging (PMMR). PMCT is particularly useful for assessing skeletal injuries, vascular lesions, and estimating post-mortem intervals. These analyses are based on radiomics principles, a growing field that requires specialized expertise, which is still limited. To support this field, post-mortem imaging biobanks are proposed as valuable tools, especially when enhanced with Artificial Intelligence (AI). However, complexities in this field require caution and adherence to guidelines, especially regarding consent for image storage, participant information, international cooperation, and nonprofit operations.