Vancomycin- induced leukocytoclastic vasculitis in a patient with end-stage renal disease: a case report and literature review.

• Tác giả: Shila Aghayani, Maryam S Fakhri B, Niloofar Khoshnam Rad, Ghazal Roostaei, Mohammad Hossein Shojamoradi, Behnoud Vesali
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences , 2025
• Bộ sưu tập: NCBI
• ID: 703668

Tóm tắt

INTRODUCTION: Leukocytoclastic vasculitis (LCV) is a small-vessel inflammatory condition that can rarely occur as an adverse drug reaction (ADR). Vancomycin-induced LCV is an uncommon but potentially serious complication, particularly in patients with pre-existing renal impairment. REASON FOR THE REPORT: This case report describes a patient with end-stage renal disease (ESRD) who developed LCV following vancomycin therapy for a catheter-related infection. The report emphasizes the diagnostic challenges and the importance of prompt and appropriate management of this ADR. A 53-year-old male with ESRD developed skin lesions and systemic symptoms after receiving vancomycin for catheter-related infection. The diagnosis of LCV was confirmed through a skin biopsy. Discontinuation of vancomycin with initiation of mycophenolate mofetil and prednisolone resulted in significant improvement in the patient's condition. OUTCOME: The presented case underlines the recognition of vancomycin-induced LCV, especially in the vulnerable population of patients with ESRD. It emphasizes the need for a high degree of suspicion of drug-related adverse events and early diagnosis and management to achieve good outcomes. CLINICAL TRIAL NUMBER: Not applicable.