Synthesis, cytotoxicity and HQSAR study of amides-fused isosteviol derivatives as potential anti-colorectal cancer agents.

• Tác giả: Xing-Jie Dai, Bing-Chao Duan, Ling-Yan Guo, Tian-Ci Li, Yu-Ling Li, Cong-Jun Liu, Wei Wang, Yong Wang, Yu-Fei Wang, Yan-Fei Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Fitoterapia , 2025
• Bộ sưu tập: NCBI
• ID: 703844

Tóm tắt

A series of novel amide-fused isosteviol derivatives were designed and synthesized. Their cytotoxicities in vitro against HCT-116 cells were screened. The preliminary bioassays indicated that most of the title compounds exhibited noteworthy cytotoxicity. Especially, the compound 33 revealed the most potent inhibitory activity with IC