Endocardial-to-mesenchymal transition underlies cardiac outflow tract septation and bicuspid aortic valve formation in the Syrian hamster model.

• Tác giả: Ana C Durán, Borja Fernández, Miguel Á López-Unzu, Laura Martín-Chaves, Bárbara Pozo-Vilumbrales, María Teresa Soto-Navarrete
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 704052

Tóm tắt

Right-left bicuspid aortic valve (R-L BAV) is the most frequent phenotype of the most common congenital heart disease. Its etiology is based on two associated morphogenetic defects during cardiac outflow tract (OFT) septation: abnormal migration of cardiac neural crest (CNC) cells, and excessive fusion of the conal ridges (CRs). The aim of this study is to elucidate the mechanism involved in the fusion of the CRs responsible for normal and abnormal OFT septation and BAV formation. Two mechanisms have been proposed: endocardial apoptosis and endocardial-mesenchymal transition (EMT). The involvement of these mechanisms in the fusion event was tested in embryos of the hamster model with BAV. Apoptotic cells were absent in the fusion area of the CRs. However, we detected endocardial cells (CD34