Readmission of patients with hypertriglyceridemia-induced acute pancreatitis: a prospective cohort study.

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Tác giả: Ling Ding, Langyi Guan, Wenhua He, Yuxiang Liu, Nonghua Lu, Liang Xia, Xin Xu, Yin Zhu

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : BMC gastroenterology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 704229

 BACKGROUND: Acute pancreatitis (AP) is a common cause of acute hospital admissions in digestive system diseases. In East Asia, hypertriglyceridemia is gradually emerged as the second most common cause of pancreatitis. Vigilance for recurrence and unplanned readmissions due to other causes is still necessary after discharge. studies on hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are scarce and mainly consists of retrospective studies. METHODS: This was a prospective cohort study of adult patients with first episode of HTG-AP from December 2019 to February 2021 who were followed up for two years. Unscheduled readmission after the index discharge was the primary outcome. The Cox proportional-hazards model, and the Fine and Gray's competing-risk model were applied to the analyses. RESULTS: Totally, 293 survival patients were followed-up after discharge. The overall unplanned readmission rate was 30.0% in two years. Among them, 60 (20.5%) patients were readmitted to hospital once, 16 (5.5%) were readmitted twice, and 13 (4.4%) were readmitted three times or more. In summary, a total of 143 cases of readmission information were collected during the follow-up period. The recurrence accounts for a significant 77.3% proportion and stands as the primary cause for readmission. Cox regression model favors infection (Hazard ratio [HR], 3.066
  95% confidence interval [CI], 1.192-7.888
  P = 0.02) and age lower than 41.5 years old (HR, 3.157
  95% CI 1.883-5.292
  P <
  0.01) as independent risk factors for patient readmission by multivariate analysis. The competing-risk model support the similar results compared with the former. CONCLUSION: Unplanned readmission of patients with hypertriglyceridemia-induced acute pancreatitis is common, especially for young patients with occurrence of any infection during hospitalization, and warrant further investigation.
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