Identifying distinct prognostic and predictive contributions of tumor epithelium versus tumor microenvironment in colorectal cancer.

• Tác giả: Ashley Alden, Domenico Coppola, Andrew Elliott, Nishant Gandhi, Sanjay Goel, Moh'd Khushman, Andrey Loboda, Emil Lou, Michelle Maurin, Michael V Nebozhyn, Lance Pflieger, W Jack Pledger, Michael J Schell, Jetsen Rodriguez Silva, George Sledge, Ramani Soundararajan, Heiman Wang, Mingli Yang, Timothy J Yeatman
• Ngôn ngữ: eng
• Thông tin xuất bản: England : BMC cancer , 2025
• Bộ sưu tập: NCBI
• ID: 704284

Tóm tắt

BACKGROUND: Accumulating evidence has suggested that cancer progression and therapeutic response depend on both tumor epithelium (EPI) and tumor microenvironment (TME). However, the dependency of clinical outcomes on the tumor EPI vs. the TME has neither been clearly defined nor quantified. METHODS: We classified 2373 colorectal cancer (CRC) tumors into the consensus molecular subtypes (CMS1-4) and generated the 10-gene TME RESULTS: The TME CONCLUSIONS: Here we identified a pair of new, distinct 10-gene signatures (the EPI