Change in diffusion weighted imaging after induction chemotherapy outperforms RECIST guideline for long-term outcome prediction in advanced nasopharyngeal carcinoma.

• Tác giả: Qi Yong H Ai, Edwin P Hui, Ann D King, Ho Sang Leung, Yannis Yan Liang, Brigette B Y Ma, Kaijing Mao, Frankie K F Mo, Lun M Wong
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Cancer imaging : the official publication of the International Cancer Imaging Society , 2025
• Bộ sưu tập: NCBI
• ID: 704318

Tóm tắt

 PURPOSE: To investigate change in diffusion weighted imaging (DWI) between pre-treatment (pre-) and after induction chemotherapy (post-IC) for long-term outcome prediction in advanced nasopharyngeal carcinoma (adNPC). MATERIALS AND METHODS: Mean apparent diffusion coefficients (ADCs) of two DWIs (ADC RESULTS: Univariable analysis showed that high ΔADC% predicted good DFS, LRRFS, and DMFS p <
  0.05), but did not predict OS (p = 0.40). Neither ADC CONCLUSION: Results suggest that ΔADC% was an independent predictor for long-term outcome and was superior to RECIST guideline for outcome prediction in adNPC. A ΔADC% threshold of ≥ 34.2% may be valuable for selecting patients who respond to treatment for de-escalation of treatment or post-treatment surveillance.