BACKGROUND: Amoebic liver abscess is a hepatic infection due to the invasion of Entamoeba histolytica. This parasitic infection is globally distributed, particularly in tropical and subtropical regions. A remarkable decline in the incidence of amoebic liver abscesses has been observed in recent years thanks to economic and public health progress. CASE PRESENTATION: This case report describes the symptoms of a 32-year-old male with an amoebic liver abscess. Despite the diagnostic difficulties encountered, favorable outcomes were obtained after the appropriate drainage of the abscess and the appropriate anti-amoebic therapy by the administration of metronidazole. CONCLUSIONS: The management of amoebic liver abscess requires a meticulous evaluation of the patient's clinical manifestations, the severity of the condition, and the response to therapeutic interventions. Early identification, combined with timely and effective treatment, is essential to reduce the risk of complications and the mortality rate. CLINICAL TRIAL NUMBER: Not applicable.