BACKGROUND: Pain in pigs needs to be managed and treated to the benefit of individual pigs. It is imperative for veterinarians and farmers to assure that pigs do not suffer from unnecessary pain that can be relieved. This review focusses on pain related to spontaneously occurring diseases and injuries since this topic is often neglected. The aim is to identify ways to accelerate knowledge and evidence in this area to prevent painful conditions in pigs in the future. METHODS: A scoping review was conducted with results from a search of the electronic databases VetSearch and CABI Rxiv. The findings of selected publications are narratively synthesized and reported orienting on the PRISMA ScR guideline. RESULTS: The results emphasize that pigs experience pain due to spontaneously occurring diseases and injuries, but systematic knowledge about this topic is scarce. More research is especially needed for rare diseases (such as UTIs). Moreover, research conducted about the topic pain in pigs should involve standardized protocols to document, analyse and share results on pain detection beyond a projects' timeframe. The findings of this review suggest that such a protocol would comprise validated pain identification measures over time and in relation to administered pain treatment. CONCLUSION: The results of this study invite veterinary practitioners to reconsider in each pig patient whether pain and related indicators are present, how to handle the situation and document the process to ensure the welfare of individual compromised pigs.