The Regulatory Role of CircAGGF1 in Myogenic Differentiation and Skeletal Muscle Development.

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Tác giả: Chunbo Cai, Wenrun Cai, Jiayi Chen, Yuxuan Gong, Xiaohong Guo, Wei Hei, Mengting Ji, Bugao Li, Meng Li, Ruotong Li, Yang Yang, Wanfeng Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Animals : an open access journal from MDPI , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 704803

Circular RNA (circRNA) has a significant impact on the maturation of skeletal muscle, although their precise functions within this framework remain largely uncharted. This study presents an investigation of the regulatory effect of circAGGF1 on myogenesis in myoblasts, including the potential molecular mechanisms involved. It is revealed that circAGGF1 facilitates the differentiation of myoblasts into other states while simultaneously enhancing the manifestation of type I muscle fibers. In vivo investigations with mice revealed the promotion of skeletal muscle expansion and maturation by circAGGF1, bolstering its regenerative capacity. Mechanistically, circAGGF1 interacts with miR-199a-3p by acting as a sponge, promoting the subsequent expression of Fgf7. Furthermore, rescue experiments indicated a counteraction of the myogenesis induced by circAGGF1 overexpression by miR-199a-3p. To summarize, this research highlights the role played by circAGGF1 in the development of skeletal muscle, providing a valuable resource for enhancing our understanding of skeletal muscle biology.
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