With the vast possibilities of restorative dentistry nowadays and the constant development and release of restorative materials with improved mechanical and esthetical properties, there is a growing body of research on adhesive systems and cementation materials, as well as the adequate choices thereof in everyday clinical practice. There are high demands from the dental cements with regard to their adhesion to various substrates and restorative materials, their mechanical properties, resistance to dissolution in the oral environment, esthetic considerations, etc. A material that meets all these requirements is not yet available, and each available material presents certain shortcomings. However, thanks to the advancements in dental material research, polymers-based cements have gained admirable mechanical and esthetic properties, as well as versatility. With the plethora of products available on the market, clinicians are often faced with difficulties in the choice of a material adequate for certain clinical situations. Indeed, important factors to consider are the substrate for cementation and the restoration material. The aim of this review was to provide clear and literature-based clinical recommendations for the adequate cementation of prosthodontic restorations with regard to the cementation substrate. Considering that there is no gold standard protocol applicable in all clinical cases, since the properties of the cementation abutment could substantially differ, important individual considerations must be made for each situation.