To address the challenges of micro-fracture development in shale formations, frequent wellbore instability, and the limited plugging capability of water-based drilling fluids in unconventional reservoirs, a nano-plugging agent (NPA) was synthesized using emulsion polymerization. The synthesized NPA was characterized through thermogravimetric analysis (TGA) and transmission electron microscopy (TEM), revealing excellent high-temperature stability and a spherical or sub-spherical morphology, with particle diameters ranging from approximately 20 to 50 nm. The rheological, filtration, and plugging properties of NPA were systematically evaluated, and its sealing mechanism was analyzed. The results demonstrate that at a test temperature of 180 °C, the optimal NPA concentration in the drilling fluid base slurry is 1.5%, achieving a 60.5% reduction in HTHP (high-temperature high-pressure) sand disc filtration loss. Additionally, the API filtration loss and HTHP filtration loss reduction rates reached 58.1% and 50.3%, respectively, highlighting the remarkable filtration loss reduction and plugging efficiency of NPA under high-temperature conditions. After NPA treatment, the specific surface area and pore volume of shale cuttings decreased to 9.348 m