Design, Synthesis, and Cytotoxicity Evaluation of Novel Indolin-2-One Based Molecules on Hepatocellular Carcinoma HepG2 Cells as Protein Kinase Inhibitors.

• Tác giả: Mohamed Kamal AbdElhameid, Mohamed Adel, Muhammad Y Al-Shorbagy, Manal M Kandeel, Ahmed T Negmeldin
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.004 Design, testing, measurement, quality, maintenance, repair
• Thông tin xuất bản: Switzerland : Molecules (Basel, Switzerland) , 2025
• Bộ sưu tập: NCBI
• ID: 705070

Tóm tắt

A series of indolinone-based derivatives were designed and synthesized using the hybrid pharmacophoric design approach as cytotoxic kinase inhibitors. The cytotoxic effects of the designed molecules were tested against MCF-7 and HepG-2 cell lines. Compounds