Metal-organic frameworks (MOFs) and their derivatives represent a novel class of porous crystalline materials characterized by exceptional porosity, high specific surface areas, and uniquely tunable physicochemical properties. These attributes render them highly promising for applications in the field of fuel cells. This review provides a comprehensive overview of the classification of MOFs and their current applications as catalysts, catalyst supports, and membranes in fuel cells. Additionally, the potential prospects and challenges associated with using MOFs and their derivatives in fuel cells are discussed, aiming to advance their development and offer valuable insights for researchers in this field.