Towards Imaging Tau Hyperphosphorylation: Is DYRK1A a Potential Target for Imaging Hyperphosphorylation of Tau? Molecular Modeling Assessment and Synthesis of [

• Tác giả: Shamiha T Ahmed, Agnes P Biju, Fariha Karim, Christopher Liang, Jogeshwar Mukherjee, Cayz G Paclibar, Deanna M Schafer, Stephanie A Sison
• Ngôn ngữ: eng
• Ký hiệu phân loại: 294.3823 Buddhism
• Thông tin xuất bản: Switzerland : Molecules (Basel, Switzerland) , 2025
• Bộ sưu tập: NCBI
• ID: 705228

Tóm tắt

Dual specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), a phosphorylation kinase, is localized within the central nervous system and is linked to hyperphosphorylation of Tau. Imaging of DYRK1A may provide an earlier biomarker for Tauopathies, including Alzheimer's disease (AD). We have used Chimera-Autodock to evaluate potential molecules for binding to the binding site of DYRK1A. Five molecules, 10-bromo-2-iodo-11