In recent years, the emergence of insecticide resistance has been a major challenge to global public health. Understanding the molecular mechanisms of this phenomenon in mosquito vectors is paramount for the formulation of effective vector control strategies. This review explores the current knowledge of insecticide resistance mechanisms through omics approaches. Genomic, transcriptomic, proteomic, and metabolomics approaches have proven crucial to understand these resilient vectors. Genomic studies have identified multiple genes associated with insecticide resistance, while transcriptomics has revealed dynamic gene expression patterns in response to insecticide exposure and other environmental stimuli. Proteomics and metabolomics offer insights into protein expression and metabolic pathways involved in detoxification and resistance. Integrating omics data holds immense potential to expand our knowledge on the molecular basis of insecticide resistance in mosquitoes via information obtained from different omics platforms to understand regulatory mechanisms and differential expression of genes and protein, and to identify the transcription factors and novel molecules involved in the detoxification of insecticides. Eventually, these data will help construct predictive models, identify novel strategies, and develop targeted interventions to control vector-borne diseases.