Genetic Polymorphisms (ApaI, FokI, BsmI, and TaqI) of the Vitamin D Receptor (VDR) Influence the Natural History and Phenotype of Crohn's Disease.

• Tác giả: Ioanna Aggeletopoulou, Evdoxia Avramopoulou, Georgios Geramoutsos, Theodora Kafentzi, Ploutarchos Pastras, Christos Sotiropoulos, Georgios Theocharis, Konstantinos Thomopoulos, Evanthia Tourkochristou, Christos Triantos, Efthymios P Tsounis
• Ngôn ngữ: eng
• Ký hiệu phân loại: 577 Ecology
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 705359
• Chủ đề: 1. Genetic; 2. Polymorphisms; 3. Apai

Tóm tắt

 Vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) modulate vitamin D/VDR signaling, a key pathway in inflammatory bowel disease (IBD) pathogenesis. This study investigates how ApaI, BsmI, TaqI, and FokI SNPs affect IBD phenotype and progression. A total of 76 Crohn's disease (CD) and 68 ulcerative colitis (UC) patients were genotyped. On initial bivariate analysis, the AA genotype of ApaI was accompanied by higher rates of penetrating (B3) CD (36.7% vs. 8.7%