Sericin, a natural macromolecular protein and the main component of silkworm cocoons, exhibits biocompatibility, excellent mechanical properties, and biodegradability. Previous research has confirmed that the sericin protein possesses anticancer properties. Gastric cancer (GC) poses a serious hazard to human health, with a low rate of early diagnosis and a poor prognosis. Investigating the safety and effectiveness of drugs for their used in treatment is imperative. In this study, we confirmed that