Comprehensive Analysis of High-Sensitive Flow Cytometry and Molecular Mensurable Residual Disease in Philadelphia Chromosome-Positive Acute Leukemia.

• Tác giả: Miriam Perlingeiro Beltrame, Carmem Bonfim, Ana Paula de Azambuja, Vaneuza Araujo Moreira Funke, Ana Lucia Vieira Mion, Ricardo Pasquini, Yara Carolina Schluga, Alexandra Cristina Senegaglia
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 705475

Tóm tắt

Monitoring measurable residual disease (MRD) is critical for the management of B-cell acute lymphoblastic leukemia (B-ALL). While a quantitative assessment of BCR::ABL1 transcripts is standard for Philadelphia chromosome-positive cases (Ph+ ALL), a multiparameter flow cytometry (FCM) is commonly used for MRD detection in other genetic subtypes. A total of 106 B-ALL patients underwent genetic and phenotypic analyses. Among them, 27 patients (20 adults and 7 children) harbored the