Mitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells.

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Tác giả: Ryan L Boudreau, Jesse D Cochran, Collin D Heer, Connor R Linzer, Douglas R Spitz, Colleen S Stein, Nathan H Witmer

Ngôn ngữ: eng

Ký hiệu phân loại: 598.635 *Bonasa

Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 705494

 Mitoregulin (MTLN) is a 56-amino-acid mitochondrial microprotein known to modulate mitochondrial energetics. MTLN gene expression is elevated broadly across most cancers and has been proposed as a prognostic biomarker for non-small cell lung cancer (NSCLC). In addition, lower MTLN expression in lung adenocarcinoma (LUAD) correlates with significantly improved patient survival. In our studies, we have found that MTLN silencing in A549 NSCLC cells slowed proliferation and, in accordance with this, we observed the following: (1) increased proportion of cells in the G1 phase of cell cycle
  (2) protein changes consistent with G1 arrest (e.g., reduced levels and/or reduced phosphorylation of ERK, MYC, CDK2, and RB, and elevated p27
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