Establishment of a Novel In Vitro and In Vivo Model to Understand Molecular Carcinogenesis of Endometriosis-Related Ovarian Neoplasms.

• Tác giả: Masako Ishikawa, Kosuke Kanno, Tohru Kiyono, Satoru Kyo, Kentaro Nakayama, Sultana Razia, Hasibul Islam Sohel, Shahataj Begum Sonia, Hitomi Yamashita, Umme Farzana Zahan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 346.0434 Private law
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 705596

Tóm tắt

The molecular mechanisms through which endometriosis-related ovarian neoplasms (ERONs) develop from benign endometrioma remain unclear. It is especially a long-standing mystery why ovarian endometrioma has the potential to develop into two representative histological subtypes: endometrioid ovarian carcinoma or clear cell ovarian carcinoma. This study aimed to investigate the molecular carcinogenesis of ERONs using newly developed in vitro and in vivo carcinogenesis models. Epithelial cells were isolated and purified from surgically removed benign endometrioma samples, followed by immortalization by overexpressing