Viral Network Analyzer (VirNA): A Novel Minimum Spanning Networks Algorithm for Investigating Viral Evolution.

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Tác giả: Martina Bado, Luca Bianco, Paolo Fontana, Enrico Lavezzo, Giorgia Mazzotti, Stefano Toppo

Ngôn ngữ: eng

Ký hiệu phân loại: 929.10284 Genealogy

Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 705636

Next Generation Sequencing technologies are essential in public health surveillance for tracking pathogen evolution, spread, and the emergence of new variants. However, the extensive sequencing of viral genomes during recent pandemics has highlighted the limitations of traditional molecular phylogenetic algorithms in capturing fine-grained evolutionary details when analyzed sequences are highly similar and datasets are large-scale. VirNA (Viral Network Analyzer) addresses this challenge by reconstructing detailed mutation patterns and tracing pathogen evolutionary routes in specific geographical regions through Minimum Spanning Networks. It enables users to analyze thousands of sequences, generating networks where nodes represent genomic sequences linked to their metadata, while edges represent potential evolutionary pathways. VirNA is a powerful tool for analyzing large, high-quality datasets, providing detailed insights into rapid pathogen evolution over short time periods, with potential applications in pandemic surveillance.
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