Synthesis of Naringenin and Senecioic Acid Ester Derivatives and Biological Evaluation of the Astrocyte Antioxidant Mechanism and Reactivity After Inflammatory Stimulus.

• Tác giả: Maria de Fátima Dias Costa, Silvia Lima Costa, Juciele Valeria Ribeiro de Oliveira, Lucas Matheus Gonçalves de Oliveira, Cleonice Creusa Dos Santos, Elivana Lima França, Heráclito Rocha Neto, Janaína Ribeiro Pereira Soares, Maurício Moraes Victor
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 705659

Tóm tắt

The imbalance between the overproduction of reactive species and antioxidant mechanisms can result in astrogliosis and oxidative stress associated with neurodegeneration. Based on the described antioxidant activity of naturally occurring flavonoids, this study evaluated the antioxidant mechanisms of the flavonoid naringenin and the senecioic acid ester derivatives in cortical astrocytes. Naringenin and (