Genetic Variants in Genes Related to Lung Function and Interstitial Lung Diseases Are Associated with Worse Outcomes in Severe COVID-19 and Lung Performance in the Post-COVID-19 Condition.

• Tác giả: Jesús Alanis-Ponce, Brandon Bautista-Becerril, Esther Blanco-Aguilar, Ivette Buendia-Roldan, Leslie Chávez-Galán, Jessica I Erives-Sedano, Ramcés Falfán-Valencia, Ingrid Fricke-Galindo, Salvador García-Carmona, Yashohara Méndez-Velasco, Karol J Nava-Quiroz, Grecia E Osuna-Espinoza, Gloria Pérez-Rubio, Juan M Reséndiz-Hernández, Fidel Salvador-Hernández, Rubén Segura-Castañeda, Uriel N Solano-Candia
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 705697

Tóm tắt

Genetic variants related to susceptibility to chronic respiratory conditions such as interstitial lung disease (ILD) could share critical pathways in the pathogenesis of COVID-19 and be implicated in COVID-19 outcomes and post-COVID-19. We aimed to identify the participation of genetic variants in lung function and ILD genes in severe COVID-19 outcomes and post-COVID-19 condition. We studied 936 hospitalized patients with COVID-19. The requirement of invasive mechanical ventilation (IMV) and the acute respiratory distress syndrome (ARDS) classification were considered. The mortality was assessed as the in-hospital death. The post-COVID-19 group included 102 patients evaluated for pulmonary function tests four times during the year after discharge. Five variants (