MELK as a Mediator of Stemness and Metastasis in Aggressive Subtypes of Breast Cancer.

• Tác giả: Reine Abou Zeidane, Alan P Boyle, Citlally Lopez Flores, Benjamin Hauk, Samuel Lichtman-Mikol, Meilan Liu, Breanna McBean, Alberto Montero, Courtney Pisano, Priyanka S Rana, Alyssa Santola, Corey W Speers, Johnathan Speers, Savannah Tidmore
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 705712

Tóm tắt

Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest prognosis and lacks actionable molecular targets for treatment. Maternal embryonic leucine zipper kinase (MELK) is highly expressed in TNBC and has been implicated in poor clinical outcomes, though its mechanistic role in the aggressive biology of TNBC is poorly understood. Here, we demonstrate a role of MELK in TNBC progression and metastasis. Analysis of publicly available datasets revealed that high