High-altitude regions offer outstanding opportunities for investigating the impacts of combined abiotic stresses on plant physiological processes given their significant differences in terms of the ecological environment in high-elevation areas, low anthropogenic disturbance, and obvious distribution characteristics of plants along altitudinal gradients. Therefore, plants in high-altitude areas can be used as good targets for exploring plant adaptations to abiotic stress under extreme conditions. Plants that thrive in high-altitude environments such as the Qinghai-Tibet Plateau endure extreme abiotic stresses, including low temperatures, high UV radiation, and nutrient-poor soils. This study explores their adaptation mechanisms via phenotypic variation analyses and multiomics approaches. Key findings highlight traits such as increased photosynthetic efficiency, robust antioxidant systems, and morphological modifications tailored to high-altitude conditions. These insights advance our understanding of plant evolution in harsh environments and inform strategies to increase stress resistance in crops.