BACKGROUND/AIMS: This study was conducted with the aim of assessing the mental well-being of general practitioners (GPs) amidst the COVID-19 pandemic in Serbia. These findings are intended to provide valuable insights to primary care stakeholders about the potential need for support interventions. MATERIALS AND METHODS: In the context of the international cross-sectional survey on primary health care during the COVID-19 pandemic (PRICOV-19), our initial focus was on evaluating the appropriateness of employing the Mayo Clinic Well-Being Index (MWBI) for Serbian GPs. The Spearman test validated the correlation between the GPs' scores of the MWBI and Depression Anxiety Stress Scales-21 (DASS21) in the Serbian context. The univariate and multivariate linear regressions modeled the personal and job-related potential predictors of higher MWBI scores ( RESULTS: A strong, positive, and significant correlation was found between the MWBI score
the total DASS21 score
and the scores for depression, anxiety, and stress ( CONCLUSIONS: The MWBI effectively assessed GPs' mental well-being amidst COVID-19 in Serbia. GPs with low socioeconomic statuses might most benefit from mental well-being support during crises. For better mental well-being, GPs need adequate time in their agendas to assess scientific evidence and adhere to established guidelines.