This study evaluates the perfection of the crystal structure of single-crystal turbine blade castings made from the CMSX-4 nickel superalloy. The analysis included primary and secondary crystal orientation measurements using the Ω-scan method and the novel OD-EFG X-ray diffractometer. The selected microstructural parameters of the single crystals were also analyzed, including the assessment of stereological parameters and the degree of porosity. A creep test was performed according to standard procedures and under conditions simulating real operational environments. The model single-crystal turbine blades were manufactured using the Bridgman-Stockbarger method, with variable withdrawal rates of 1 and 3 mm/min. Heat treatment of the single-crystal castings involved solution treatment followed by double aging. The evaluation of structural perfection was carried out in three states: as-cast, after solution heat treatment, and after double aging. The crystallographic orientation of the blades was determined on both the airfoil and the root part. The study determined how crystallographic orientation and microstructural parameters influence the creep resistance of the castings. It was found that in the as-cast condition, the greatest influence on high creep strength has a small deviation of the primary and constant value of secondary crystal orientation along the height of the blade casting. After heat treatment, the highest creep resistance was obtained for the blade manufactured at a withdrawal rate at 1 mm/min.