Efficacy and Safety of Accelerated Transepithelial Corneal Crosslinking in Non-Pediatric Patients with Progressive Keratoconus: Insights from a Retrospective Cohort Study.

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Tác giả: Diana Barakat, Alina-Cristina Chiraples, Diana-Maria Darabus, Mihnea Munteanu, Alina-Gabriela Negru, Horia T Stanca

Ngôn ngữ: eng

Ký hiệu phân loại: 944.031 Reign of Henry IV, 1589—1610

Thông tin xuất bản: Switzerland : Healthcare (Basel, Switzerland) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 706199

BACKGROUND/OBJECTIVES: Transepithelial accelerated corneal crosslinking (TE-ACXL) is a minimally invasive approach for stabilizing progressive keratoconus while preserving the corneal epithelium. This study aims to evaluate changes in visual acuity, refractive error, and corneal parameters before and six months after TE-ACXL. METHODS: A retrospective analysis was conducted on 30 eyes from 20 patients who underwent TE-ACXL between May 2021 and June 2023. Variables included were uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), spherical and cylindrical refractive error, and corneal tomography parameters such as maximum keratometry (Kmax), the symmetry index (Si), the keratoconus vertex (KV), Baiocchi-Calossi-Versaci index (BCV), thinnest corneal thickness (TCT), and central corneal thickness (CCT). RESULTS: CDVA improved from 0.20 ± 0.22 to 0.06 ± 0.11 LogMAR ( CONCLUSIONS: TE-ACXL was associated with significant improvements in visual acuity and refractive stability at six months postoperatively while maintaining a favorable safety profile. The procedure may serve as an effective option for early intervention in progressive keratoconus.
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