A miniaturised, eco-friendly and efficient multiclass method for the simultaneous determination of 87 veterinary drugs, pesticides and mycotoxin residues in beef muscle samples by ionic liquid-based dispersive liquid-liquid microextraction (IL-DLLME) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed and validated according to Commission Implementing Regulation (EU) 2021/808 and ISO/IEC 17025: 2017. Under IL-DLLME optimum conditions, matrix calibration yielded a coefficient of determination (