Mixture Design and Doehlert Matrix for Optimization of Energized Dispersive Guided Extraction (EDGE) of Theobromine and Caffeine from Cocoa Bean Shells.

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Tác giả: Paulo Natan Alves Dos Santos, Elina Bastos Caramão, Larissa da Silveira Ferreira, Bruna Louise de Moura Pita, Fabio de Souza Dias, Lisiane Dos Santos Freitas, Allan Dos Santos Polidoro, João Victor Ferreira Lima, Alini Tinoco Fricks, Honnara Santos Granja, Luciana Lordêlo Nascimento

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Foods (Basel, Switzerland) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 706437

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This work describes the development of a method for the extraction of methylxanthines from cocoa bean shell (CBS) by employing the novel Energized Dispersive Guided Extraction (EDGE) system. The mixtures were composed of ethanol-methanol-water and the ratio was optimized using a simplex-centroid design. Doehlert design (DD) was used to optimize the variables of temperature and time while using methylxanthine content obtained by HPLC-DAD as an analytical response. The optimized mixture consisted of water-ethanol in a 3:2 ratio. The optimum operating conditions for extraction were achieved at a temperature of 148.5 °C and 382 s. Under optimal conditions, 20.14 mg g

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