Physiologically based pharmacokinetic (PBPK) models use a mechanistic approach to delineate the processes of the absorption, distribution, metabolism and excretion of biological substances in various species. These models generally comprise coupled systems of ordinary differential equations involving multiple states and a moderate to a large number of parameters. Such models contain compartments corresponding to various organs or tissues in the body. Before employing the models for treatment, the quantification of uncertainties for the parameters, based on