Investigation of structural and dynamic properties of the Butyrophilin BTN3A1/BTN2A1 cytoplasmic complex by

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Tác giả: Chia-Hung Christine Hsiao, Yiming Jin, Khiem Nguyen, Olga Vinogradova, Andrew J Wiemer

Ngôn ngữ: eng

Ký hiệu phân loại: 001.434 Experimental method

Thông tin xuất bản: United States : FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 706882

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Butyrophilin 3A1 (BTN3A1) is an integral membrane protein capable of detecting phosphoantigens, like (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), through its internal B30.2 domain. Detection of phosphoantigens leads to interactions with butyrophilin 2A1 and the subsequent activation of γδ-T cells. Though crystallography and functional assays have been crucial for determining vital residues of the BTN3A1/HMBPP/BTN2A1 complex, the mechanism for signal transduction is still unclear. Here, we utilize

1. Investigation
2. Of
3. Structural

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