Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity.

• Tác giả: Shihui Chen, Carolyn Marie Phillips
• Ngôn ngữ: eng
• Thông tin xuất bản: England : eLife , 2025
• Bộ sưu tập: NCBI
• ID: 706993

Tóm tắt

RNA interference (RNAi) is a conserved pathway that utilizes Argonaute proteins and their associated small RNAs to exert gene regulatory function on complementary transcripts. While the majority of germline-expressed RNAi proteins reside in perinuclear germ granules, it is unknown whether and how RNAi pathways are spatially organized in other cell types. Here, we find that the small RNA biogenesis machinery is spatially and temporally organized during