New oxepin and dihydrobenzofuran derivatives from Bauhinia saccocalyx roots and their anti-inflammatory, cytotoxic, and antioxidant activities.

• Tác giả: Kiattawee Choowongkomon, Supachai Jadsadajerm, Sutin Kaennakam, Thanyathon Phonchan, Chanikan Sonklin, Lueacha Tabtimmai, Natrinee Thongprik, Awat Wisetsai, Nuttapon Yodsin
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.8014 *Romania
• Thông tin xuất bản: Japan : Journal of natural medicines , 2025
• Bộ sưu tập: NCBI
• ID: 707391

Tóm tắt

Four new oxepin and dihydrobenzofuran derivatives, saccoxepins A-C (1-3) and saccobenzofurin A (4), along with one known compound, bauhinoxepin A (5), were isolated from the roots of Bauhinia saccocalyx. The structures were elucidated by extensive analysis of spectroscopic data in combination with ECD analysis. The EtOAc extract exhibited significant NO inhibition (94.4 ± 0.35%, 50 μg/mL), and saccoxepin A and bauhinoxepin A demonstrated strong NO suppression, with IC