Nanoparticle (NP)-doped polymer waveguide devices have attracted increasing interest in some rapidly developing areas of broadband communications because they are easy to integrate on chip. As an important part of the gain medium of waveguide amplifiers, lanthanide-doped nanoparticles have been widely studied to improve the amplification performance of devices. However, current research work is almost limited to erbium-doped nanoparticles and amplifiers operating in the C-band. Implementing the O-band optical amplification technology remains a challenge. Here, we report a method for preparing O-band waveguide amplifiers using Yb