We propose a Bayesian inference estimation of in-medium modification of the cluster self-energies from light nuclei multiplicities measured in selected samples of central ^{136,124}Xe+^{124,112}Sn collisions with the INDRA apparatus. The data are interpreted with a relativistic quasiparticle cluster approach in the mean-field approximation without any prior assumption on the thermal parameters of the model. An excellent reproduction is obtained for H and He isotope multiplicities, and compatible posterior distributions are found for the unknown thermal parameters. We conclude that the cluster-σ-meson coupling is temperature dependent, becoming weaker when the temperature increases, in agreement with microscopic quantum statistical calculations. This implies a faster decrease of the light cluster abundances with temperature than previously estimated.