Senolytic treatment for low back pain.

• Tác giả: Hosni Cherif, Elsa Cousineau, Chan Gao, Saber Ghazizadeh, Alice Gilbert, Lisbet Haglund, Seunghwan Lee, Matthew Mannarino, Oliver Wu Martinez, Magali Millecamps, Reza Sharif Naeini, Jean A Ouellet, Cedric Peirs, Laura S Stone, Kai Sheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.133349 Aerospace engineering
• Thông tin xuất bản: United States : Science advances , 2025
• Bộ sưu tập: NCBI
• ID: 707638

Tóm tắt

Senescent cells (SnCs) accumulate because of aging and external cellular stress throughout the body. They adopt a senescence-associated secretory phenotype (SASP) and release inflammatory and degenerative factors that actively contribute to age-related diseases, such as low back pain (LBP). The senolytics,