The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins.

• Tác giả: Bettina Brokowski, Janne M Colding, Luuk R H Dijkhof, Roberta Florea, Alexander S Hauser, Christine C Jao, Prajakta Joshi, Marc Kschonsak, Alexander Leitner, Stephan A Pless, Christian Rosenmund, Estelle Toulmé, Thorsten Trimbuch, Samuel Usher, Stanislau Yatskevich, Inna Zilberleyb
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Science advances , 2025
• Bộ sưu tập: NCBI
• ID: 707639

Tóm tắt

NALCN (sodium leak channel, nonselective) is vital for regulating electrical activity in neurons and other excitable cells, and mutations in the channel or its auxiliary proteins lead to severe neurodevelopmental disorders. Here, we show that the neuronal SNARE (soluble