Long-term functional outcomes after Transanal Transection and Single-Stapled (TTSS) anastomosis for rectal cancer measured by electronic Patients Reported Outcome Measures (ePROMs).

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Tác giả: Michele Carvello, Caterina Foppa, Carlotta La Raja, Antonio Luberto, Annalisa Maroli, Maria Rocca, Antonino Spinelli, Federico Zangrandi

Ngôn ngữ: eng

Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a

Thông tin xuất bản: England : European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 707859

BACKGROUND: The transanal transection and single-stapled anastomosis (TTSS) is gaining interest as a reconstructive technique whenever a restorative procedure after a total mesorectal excision (TME) is planned. TTSS, allowing lower anastomoses than the conventional DS technique, may raise discussion about its functional outcomes. The aim of this study was to compare long-term functional outcomes of TTSS and DS techniques performed after TME for rectal cancer (RC). METHODS: This was a prospective, observational, two-parallel cohort study. Consecutive patients undergoing stoma closure after TME for RC with either TTSS or DS approach were included. The Low Anterior Resection Syndrome (LARS) questionnaire was delivered at 6, 12, and 24 months after stoma closure through a web link embedded in a Short Message System (SMS) or email using an electronic system (Esosphera Srl). RESULTS: According to sample size calculation, 116 patients (58 per cohort) were included. No difference in the LARS score was found at 6 and 12 months, while a significantly lower median LARS was reported in TTSS cohort at 24 months (p = 0.034). The rate of patients with LARS and LARS sub-domains were comparable except for a lower fractioning in TTSS at 24 months (p = 0.005). Anastomoses in the TTSS cohort were significantly lower (p = 0.027), anastomotic leak rate was higher in the DS (p = 0.016). CONCLUSIONS: Although lower anastomoses in TTSS cohort, functional outcomes were not inferior of those after DS technique.
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