This case report aims to demonstrate the use of amniotic membrane transplantation (AMT) as a treatment for a refractory full-thickness macular hole (FTMH) that developed secondary to neuroretinitis. A 14-year-old girl presented to our hospital with a complaint of blurred vision persisting for one week. The patient was diagnosed with neuroretinitis due to cat scratch disease with a FTMH that developed secondarily. A pars plana vitrectomy, internal limiting membrane (ILM) peel, and ILM transplantation were performed. The FTMH did not close completely. The third surgery was performed using the AMT method, which resulted in the successful closure of the FTMH. This is the first case report documenting the treatment of refractory FTMH secondary to neuroretinitis using AMT. It can be suggested that inflammation plays a role in the pathophysiology of FTMH secondary to neuroretinitis. We consider AMT to be an effective method in the treatment of resistant FTMH.